The aim of this clinical guideline is to evaluate the benefits and threats/harms of using proton therapy in primary treatment and salvage therapy with respect to survival, disease progression, toxicity and quality of life for the treatment of cancer in pediatric patients compared to other types of radiotherapy, and to formulate recommendations for clinical practice.

Clinical questions relate to the following types of tumors in children:

brain, spinal cord, paraspinal tumors head and neck tumors lymphomas eye tumors sarcomas bone tumors.