Evidence-based recommendations on percutaneous transluminal renal sympathetic denervation for resistant hypertension. This involves inserting a device through the skin (percutaneous) into an artery in the thigh and then into the renal arteries (transluminal). It sends radio or sound waves to destroy the nerves in the renal arteries (sympathetic denervation). The aim is to lower blood pressure. Is this guidance up to date? Next review: 2026 Guidance development process How we develop NICE interventional procedures guidance Coding and clinical classification codes for this guidance. This guidance replaces NICE interventional procedures guidance on percutaneous transluminal radiofrequency sympathetic denervation of the renal artery for resistant hypertension (IPG418).