This Web Annex provides detailed information on the processes, procedures and methods for developing Guidelines on the management of chronic pain in children. These guidelines were developed according to World Health Organization (WHO) guidance on guideline development: WHO handbook for guideline development (2nd edition, 2014).

1 The main steps for developing WHO guidelines include:

1) establishment of the general scope of the guideline and development of the key questions; 2) identification of contributors to the guideline process: 3) performance of systematic reviews of the evidence to address the key questions; 4) assessment of the quality (certainty) of the body of evidence for important and critical outcomes; 5) formulation of recommendations and drafting of the guideline document; 6) review and approval by the Guideline Development Group (GDG); 7) external peer review; 7) review and approval by WHO’s internal quality assurance processes; and 8) publication and dissemination.