The use of molecular line probe assays for the detection of resistance to second-line anti-tuberculosis drugs: policy guidance
Ano de publicação: 2016
This document provides a summary of the evidence and recommendations for the use of SL-LPA for the detection of mutations associated with resistance to fluoroquinolones and SLID in patients with RR-TB and/or MDR-TB. The objectives of this policy guidance are to assess and compare the diagnostic accuracy of SL-LPA for the detection of resistance to fluoroquinolones in sputum specimens (using direct testing) and culture isolates (using indirect testing) confirmed as M. tuberculosis complex and to assess and compare the diagnostic accuracy of MTBDRsl for the detection of resistance to SLIDs in sputum specimens (using direct testing) and culture isolates (using indirect testing) confirmed as M. tuberculosis complex.
Tuberculosis, Multidrug-Resistant/diagnosis, Antibiotics, Antitubercular/pharmacology, Molecular Probe Techniques, Microbial Sensitivity Tests, Fluoroquinolones/therapeutic use, Drug Resistance, Bacterial/genetics, Genotype, Mutation, Tuberculosis, Multidrug-Resistant/genetics, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis/genetics